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The authors concluded that larazotide acetate reduced IEB permeability assessed by lactulose/mannitol permeability test, proinflammatory cytokine production, and gastrointestinal symptoms in CD after gluten exposure (279)
Although it remains unknown whether the absolute or change in onset threshold better reflects thermoregulatory control, studies should consider whether the effect of a given modulator on the onset threshold goes beyond any change in resting deep body temperature
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