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This includes SCS, which involves the surgical implantation of electrodes in the epidural space to deliver electrical pulses to the dorsal columns, masking pain signals through mechanisms such as enhanced GABAergic inhibition [368, 370], and peripheral nerve stimulation (PNS), which involves implanting electrodes along specific peripheral nerves [41, 45]

Superoxide dismutase (SOD) activity was quantified using a commercial kit, based on the inhibition of WST-1 formazan dye generation

Visible physical changes (body composition, skin texture) appear at 8-12 weeks

TM's efficacy has also been investigated in animal models of inflammatory and immune-related diseases (24, 25), but clinical studies are needed to evaluate whether copper depletion might stabilize diseases and improve survival in humans, as suggested by a trial of TM therapy with patients with biliary cirrhosis (26)