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Recent advances in Alzheimers disease: mechanisms, clinical trials and new drug development strategies

Oxidative stress occurs when the organism is subjected to a variety of internal and external environmental stimuli and there is an imbalance between oxidative and antioxidant processes

69,70 Concurrently, the Wnt/-catenin pathway contributes to self-renewal via TCF/LEF-mediated transcription of stemness-related genes, although excessive activation of this pathway can cause aberrant proliferation

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