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Upon receptor activation, IGF1R autophosphorylates on tyrosine residues 1131, 1135, and 1136 in the activation loop

[DOI: 10.1371/journal.pmed.1000100] [DOI] [PMC free article] [PubMed] [Google Scholar] Lindenbaum 1994 Lindenbaum J, Rosenberg IH, Wilson PW, Stabler SP, Allen RH

You may have some pain, swelling or itching where you had the injection

In cases like these, you just cant rely on once-a-week or once-a-month shots, which are unfortunately the doses doctors most often prescribe
