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Uberti F, Ruga S, Farghali M, Galla R, Molinari CA
Binding of cobalamin to IF occurs within the duodenum and jejunum of the small intestine, before IF acts to facilitate the subsequent absorption of cobalamin in the ileum (Caldern-Ospina and Nava-Mesa, 2020) (Fig 4)
The commonly referenced therapeutic range of 0.25-0.5 mg daily (250-500 mcg) extrapolates from the effective rat dose of approximately 10 mcg/kg body weight
10.1002/anie.201107724 24 FarzaeiM
