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The activation of the serotonergic neurons leads to the hyperpolarization of NPY/AgRP neurons and to the depolarization of POMC/CART neurons

To address whether LIP-induced cell proliferation critically depends on glycolysis or mitochondrial respiration we performed dose-response experiments using either the glycolytic inhibitor 2-deoxyglucose (2-DG) or the mitochondrial complex 1 inhibitor rotenone

Clinical trials have shown promising results, highlighting its effectiveness in improving glycemic control and aiding weight loss in individuals with Type 2 diabetes and obesity

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