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Terrier P, Townsend AJ, Coindre JM, Triche TJ, Cowan KH (October 1990)

The resounding answer is that sustained weight loss must involve lifestyle changes

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors
Our bodies are able to naturally produce GSH, however, production decreases with age, and we can quickly become overwhelmed with toxins and other offenders that deplete it