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High circulating TMAO correlates with increased brain proinflammatory cytokines and astrocyte activation markers (144)

Western Blotting The protein levels of dynamin-related protein (Drp)-1, fission protein (Fis)-1, phosphatase and tensin homolog induced putative kinase (Pink)-1, Parkin, optic atrophy (Opa)-1, light chain 3 microtubule-associated protein A/B (LC3A/B), manganese superoxide dismutase (MnSOD), translocase of outer membrane (Tom)-20 and OXPHOS complexes were measured by western blotting

L-Carnitine performs as a substrate to carry on this process of transporting long-chain fatty acids to the mitochondria of the cells to be metabolized into energy

Keywords: mitochondrial function, l-carnitine, fatty acid oxidation, glycolysis, ketogenesis, beta oxidation, metabolic inflexibility, diabetes, neurodegeneration, liver disease 1