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Description
The acidic brain-glycolytic switch in the microenvironment of malignant glioma
Media were supplemented with indicated compounds (Sigma-Aldrich, unless noted): 5 mM glucose, 2 mM l-glutamine (Thermo Fisher Scientific), 5 mM pyruvate, 5 mM dimethyl-2-oxoglutarate, 2 mM glutamate, 2 mM NAC, or 1 M Telaglenastat (CB-839
R., van de Velde, C
Binding affinities, measured in kilocalories per mole (kcal/mol), were used to determine the optimal docking pose, identified as the conformation with the lowest binding energy
