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In summary, this glycolysis-centered metabolic reprogramming not only provides essential energy for the abnormal proliferation of leiomyoma cells but also influences the physiological state of surrounding tissues by altering the metabolic microenvironment (such as acidification and lactate signaling), constituting a key mechanism for the sustained growth of uterine fibroids

The figure summarizes the main challenges identified in the Discussion regarding the translation of NRF2 modulation into clinical practice

Laser acupuncture at GV20 improves brain damage and oxidative stress in animal model of focal ischemic stroke

Santen RJ, Brodie H, Simpson ER, Siiteri PK (2009) History of aromatase: saga of an important biological mediator and therapeutic target
