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In Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics (eds
Additional large scale prospective controlled studies should be conducted to evaluate the safety of coffee enema use
This review systematizes current data on the mechanisms of nAbs formation against AAV vectors, analyzes the factors influencing their production, and discusses strategies to overcome this limitation, including modification of vectors and the development of methods to suppress the immune response
However, outcomes depend heavily on dosage, treatment frequency, and patient metabolism
