glutathione with electrophile Electrophiles modulate reductase activity via alkylation and upregulation of glutathione biosynthesis It favors its accumulation in the regions of high electron flux in cells where reactive species are generated. Schematic view of glutathione and

Description

While insulin resistance is a hallmark of the disease, it is insufficient insulin secretion from the beta cell that ultimately drives the transition to hyperglycaemia

Acknowledgements This study was supported by the UK Research and Innovation (UKRI) Medical Research Council (MRC) under grant number MR/V001264/1, awarded to M.J.I.P., D.W., G.L and H.M.I

Melgoza, L

Beyond scientific interest, these findings have translational relevance, as modulating adipocyte function or addressing eating behaviors could serve as potential targets for adjunctive therapies in MM (95, 101)