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Description
Phosphorylation of the DSGIS motif in NRF2 mediated by glycogen synthase kinase-3 beta (GSK-3) promotes the binding of -TrCP to NRF2 which is therefore marked for ubiquitination and then degraded by the proteasome [145, 149,150,151]
10.1126/science.1085953 101
Int J Mol Sci 22:4094
Establishing the orthotopic pancreatic cancer models BALB/c nude mice (male, 8 weeks, 18-20 g) were acquired from Beijing Vital River Laboratory Animal Technology Co., Ltd
