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Chronic alcohol consumption causes hepatic mitochondrial dysfunction and reduces ALDH activity, leading to acetaldehyde accumulation [25]
Total concentrations of Pycnogenol constituents and metabolites were quantified in serum (see section 4.1 Absorption into plasma/serum and concentration profiles), synovial fluid (see section 5.4 Distribution into synovial fluid) and blood cells (Table 2)
Scientific References: Pompella, A., Visvikis, A., Paolicchi, A., De Tata, V., & Casini, A
