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Although Slc7a5 -/- CD4 + T cells do not differentiate into Th1 and Th17 cells, differentiation into iTreg is not affected ( + T cells in both human cells and imiquimod (a TLR7 agonist)-induced lupus and psoriasis-like animal models ( Figure 1 )

By contrast, in the GSH-C4-first sequence (Figure 3B), HA + GSH-C4 elicited a reproducible cytokine activation profile: at V3, levels of IFN-2 (p = 0.044), IFN- (p = 0.023), TNF- (p = 0.039), IL-6 (p = 0.044), IL-12p70 (p = 0.015), IL-23 (p = 0.034), and the epithelial alarmin IL-33 (p = 0.023) were significantly elevated versus baseline, whereas IL-1, MCP-1, IL-8, IL-10, and IL-18 remained unchanged

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