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127 Interestingly, a study in patients with severe obesity found that among BCKAs, ketoisovalerate (KIV) and the ratio of BCKA/BCAA showed a positive association with both the steatosis grade and NASH 11 indicating the ratio of BCKA/BCAA could serve as a robust biomarker for the liver disease instead of relying on either BCAAs or BCKAs, and defective BCAA catabolism might causatively contribute to the development of MAFLD

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Natural ProductTargeted Delivery Systems: Tumor Metabolism and Microenvironmental Adaptation The therapeutic efficacy of natural products is often limited by their poor bioavailability and nonspecific distribution

The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila