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We demonstrated that aging rats exhibited increased accumulation of lipid peroxides and enhanced ferroptosis in the heart, while administration of a ferroptosis inhibitor effectively attenuated the decline of cardiac function in aging rats
FEBS J 2007
Structureactivity relationship studies indicate that potential nitrile oxide species derived from diacylfuroxan bind specifically to the catalytic (seleno)cysteine residue 46 of GPX4 [219]
doi: 10.1021/acs.jafc.8b00860
