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[DOI] [PMC free article] [PubMed] [Google Scholar] Delafontaine P, Bernstein KE, Alexander RW

Notably, the rate of degradation increases with increasing temperature, whereas the antioxidant activity correspondingly decreases with both elevated temperature and prolonged exposure time

A previous meta-analysis of 6 studies among hemodialysis patients, concluded that intravenous STS could attenuate the progression of macrovascular calcification among hemodialysis patients and help ameliorate arterial stiffness in hemodialysis patients (Wen et al, NDT 2022)

the real safety question is context, not the molecule itself