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In animal models of ALS, dysfunction of mitochondria in motor neurons occurs before any other observable pathologic changes, suggesting this is an early event in the progression of the disease (Kong 1998)
Although the ultimate reason for high circulating levels of ferritin in these cases may be challenging to identify, elevated serum ferritin levels provide access to adequate iron quantities for supplying tumors that possess enhanced iron metabolism
Biosynthesis of riboflavin in Archaea 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii
Mood disturbances, including irritability or depression
