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Springer International

The activation of PLC results in the release of inositol-1,4,5-trisphosphate (IP 3 ) from membrane associated phosphatidylinositol-4,5-bisphosphate (PIP 2 ), which then binds to specific IP 3 receptors in the endoplasmic reticulum/sarcoplasmic reticulum (ER/SR) resulting in the release of intracellular stores of Ca 2+

Plasma samples for the measurement of ALCAR and L-carnitine levels were taken pre-dose (fasting) and 2-hour post-dose
