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Although human nitrate reductase activity has been posited as a secondary function of xanthine oxidase (XO, vide infra ), especially for organic nitrates (RONO 2 ) (Millar et al ., 1998
doi: 10.4081/jbr.2021.9954
Research has shown that cream with niacinamide enhances skin barrier function before application of 0.025% Vitamin A and significantly reduces skin irritation such as dryness or peeling, burning, and stinging [5]
It also demonstrated stronger immune responses and a reduction in oxidative stress markers like MDA
