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De Angelis, M
Steric hindrance from the increased side-chain volume of E14 Cagri and R17 Cagri promotes a shift of the -helix of Cagri away from ECL2 and a slight expansion of the peptide binding pocket at the extracellular side of the CTR TM domain, relative to those observed with rAmy/San385-bound AMYR complexes
Additionally, some mechanistic inferences are based on observational data of metabolite levels or single-gene regulation, lacking causal validation via interventional experiments
Pycnogenol improvements in asthma management
