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Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation
Magnani F
When portal insulin levels are low (e.g., during fasting and in T1DM), the low insulin activity in the liver must be able to lower IGF-1 secretion and reduce its activity to prevent IGF-1-induced hypoglycemia by binding to the INSR, as the IGF-1 concentrations are significantly higherenough to compensate for the lower affinity of IGF-1 to the INSR
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