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doi: 10.3168/jds.2017-13707 42 EstesK

The addition of exogenous ROS results in resensitization of cells with high VRK2 expression to GSH inhibition, which is consistent with the fact that PC cells with low expression of VRK2 are susceptible to GSH inhibition attributes to its high basal ROS level, suggesting that cells in a state of oxidative stress have enhanced dependence on the GSH system

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found that leukocytes may induce sperm DNA damage with cascade amplification effects, while affected patients have significantly increased ROS production rates and reduced sperm motility