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Safety assessments comprised physical examination, vital signs (blood pressure, pulse rate, body temperature), supine 12-lead ECG recordings and laboratory tests

Identification of caspase-8 as a cell fate-regulating enzyme in mature erythrocytes might have far-reaching implications for RBC biology, since the ability to regulate and select cell death modalities questions a conceptual view on erythrocytes as entities existing in a state between life and death

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Evaluation of oxidative stress parameters in blood of patients with laryngeal carcinoma