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Several studies have indicated that spinach leaves contain several powerful and water-soluble natural antioxidants with potential biological activities (14,2527)

[7] [8] [2] The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer

Several studies have noted elevated activity in other limbic and subcortical areas, including insula, ventral striatum, putamen, hypothalamus, and thalamus, in bipolar depression relative to healthy controls (106, 137, 139)