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Finally, while sulforaphane is generally well-tolerated at low dose, clinical trials as higher sulforaphane doses can have unwanted side effects, such as lethargy, hypothermia, and gastrointestinal distress, although these generally occur at very high doses (Yagishita et al., 2019)
The T-AOC can be determined by measuring the absorbance of ABTS + at 734 and 405 nm

Issues such as biocompatibility and safety concerns, the complexity of manufacturing and quality control, optimization of drug delivery efficiency, understanding of nano-bio interface interactions, assessment of long-term side effects and cumulative toxicity, cost issues, the complexity of clinical trial design, and drug resistance are all challenges that must be faced in the clinical translation of nanomedicine

Li Y, North RY, Rhines LD, Tatsui CE, Rao G, Edwards DD, et al
