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Pettinger WA, Soyangco F, and Oates JA, Inhibition of Monoamine Oxidase in Man by Furazolidone, Clin Pharmacol Ther , 1968, 9:442

Although increasing the cohort size above six results in little increase in the probability of observing a given event, the higher the sample size the greater the probability for observing an event that is not due to a study drug but is simply part of the spontaneous event rate for that event

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After first entry, an opened repeated-entry vial is generally dated and discarded within 28 days unless the manufacturer states another period.
