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Bulletin of experimental biology and medicine , 154 (3), 403410

By use of micropuncture studies in rats with adriamycin-induced nephrotic syndrome, they could demonstrate that IGF-1 serum concentrations are markedly reduced and IGF-1 is highly ultrafiltrated together with IGFBP-2 appearing in proximal tubular fluid [217]

When the skin is exposed to sunlight, melanocytes accelerate the synthesis of melanin and darken the skin color, thereby absorbing and scattering ultraviolet light and reducing ultraviolet damage to skin cells