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Description
Individual protocols must be personalized based on body composition, metabolic status, and physician assessment
The oral LD 50 of MEVA was determined to be 4808.33 mg/kg body weight in adult Wistar rats (Table 1)
doi: 10.1111/j.1476-5381.2012.01970.x 147
Major translational challenges are efficient drug delivery to posterior segment tissues (oral, topical, and intravitreal routes each present specific challenges), addressing systemic side effects (e.g., niacin-associated flushing), and addressing patient-to-patient heterogeneity in receptor expression and pharmacodynamics
