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Plexins may also function as RanGAPs within the cytoplasm, liberating importins from RanGTP-importin complexes to allow their binding to more cargo

Significantly, FUS phosphomimetic substitution reduces aggregation in human cells and yeast models and controls FUS-associated cytotoxicity 82

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Based on his investigations into dyes and experiments with plant poisons as well his collaboration with von Behring to develop antiserum to treat diphtheria and tetanus, Ehrlich proposed that certain foreign entities, like toxins, get recognised by specific side chains on the cell which trigger the release of additional side chains into the bloodstream where they manage to bind and neutralise the toxin