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Such a system could help define functional subtypes based on pathogenic processes rather than surface phenotype alone

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doi: 10.1016/j.exer.2022.109364 225 BiesemeierAYoeruekEEiblOSchraermeyerU

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For all brain scans, the slices were positioned to run parallel to a line that joins the most infero-anterior and infero-posterior parts of the corpus callosum (ACPC line), covering the entire brain from the skull base to the vertex, with careful repositioning during the follow-up scan

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