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After being fed HFD for a total of 16-weeks (an appropriate rodent model of DIO and comparable to human obesity [21]) and reaching pre-arrival body weights (~38g), mice were randomized into balanced control and treatment cohorts (n=9/cohort), with similar group average body weight and standard deviation

The fact is that GP audits (and no clinical evidence or patient involvement of any kind) eventually made three monthly injections the optimal maintenance dose of B12