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Indeed, mass spectrometry analysis in healthy hearts from animal models after 54 weeks of moderate treadmill exercise show an increase in mitochondrial protein content with specific reprogramming of the phosphoproteome (Ferreira et al., 2014)
Considering the tissue selectivity of 1,2-DCP-related to cancer risk in humans, this biliary excretion of 1,2-DCP metabolites would be responsible for the cholangiocarcinoma
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