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As a result of the failure of phagocytes to mount a respiratory burst, the majority of CGD patients are susceptible to recurrent and life-threatening bacterial and fungal infections early in childhood, due to ineffective killing and containment of the pathogens (van den Berg et al., 2009

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However, pharmacological inhibition of glutamine utilization in mice also altered the phenotype and effector function of tumor-infiltrate lymphocytes

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