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Clinical trials evaluating anti-inflammatory agents in MIRI have yielded mixed but overall more encouraging results compared to broad antioxidant supplementation (summarized in Table 1)

Future research should focus on optimizing AgNP synthesis methods, improving their biocompatibility, and conducting rigorous clinical trials to validate their safety and efficacy

Additionally, exposure to ROS can lead to modifications that cause genomic DNA mutations, negatively affect protein activity, damage cellular membranes, and eventually leading to cell death

These results imply that aSYN might influence vesicle fusion during synaptic stimulation and the distribution of vesicles between the ready releasable and reserve synaptic pools, acting as a negative regulator of dopamine release