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Description
10.3324/haematol.2011.049957 130
This metabolic reprogramming serves as a crucial source of energy for rapidly proliferating cells, notably tumor cells and inflammatory cells, augmenting their capacity to adapt to hypoxic conditions
The good performance of the approach during in vitro tests on cell lines is only a stepping stone towards the results obtained in vivo, which are especially impressive
Despite research efforts to understand the mechanism by which the redox signal is transmitted from oxidant to specific proteins and in particular how Grx is activated to reverse or put forward glutathionylation, much remains to be elucidated
