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doi: 10.1016/0092-8674(94)90212-7

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10.1093/oxfordjournals.pcp.a029285 55 IshikawaT.SakaiK.YoshimuraK.TakedaT.ShigeokaS

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After ingestion, folate from food is hydrolyzed in the gut, where it is converted first to tetrahydrofolate by the enzyme dihydrofolate reductase and then to the active form 5-MTHF, by the enzyme MTHFR

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