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doi: 10.1016/0092-8674(94)90212-7

10.1093/oxfordjournals.pcp.a029285 55 IshikawaT.SakaiK.YoshimuraK.TakedaT.ShigeokaS

After ingestion, folate from food is hydrolyzed in the gut, where it is converted first to tetrahydrofolate by the enzyme dihydrofolate reductase and then to the active form 5-MTHF, by the enzyme MTHFR

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