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Failure to degrade damaged mitochondria in a timely manner triggers a vicious cycle of sustained PANoptosis activation

IF is very specific for cobalamin (i.e

Figure 1 Important developments in the field over this time include the first clinical descriptions of the inborn error of metabolism disorder homocystinuria and the subsequent discovery of severe genetic defects in enzymes involved in homocysteine metabolism as causative factors (4)

However, many people, especially those following a plant-based diet or individuals with certain medical conditions, may find it challenging to get enough vitamin B12