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The standard curve plasma samples were then stored at -20C and further processed alongside the pharmacokinetic study samples according to the method described above

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Even within the same tumor, some CSC clones can express high levels of drug efflux transporters, DNA repair enzymes, and antiapoptotic proteins, enabling them to survive treatment, whereas others cannot

*Correspondence: Ling Liu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers