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As discussed earlier, Koeth et al.'s study on gut microbiota-induced TMAO in stable patients undergoing cardiac evaluation showed significant dose-dependent associations between plasma L-carnitine levels and risks of coronary artery disease, peripheral artery disease, and overall CVD after correction for common CVD risk factors [18]

A total of 23 patients (16.7%) reported adverse events, including insomnia, shivering, headaches, and nausea

There was no significant difference in terms of age ( P = 0.58), sex ( P = 1), systolic ( P = 0.4) or diastolic ( P = 0.88) blood pressure, marital status ( P = 0.69), smoking status ( P = 0.61), or comorbidity status ( P = 1) between the L-carnitine group and the placebo group