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Description
48 Thalidomide remains controversial due to its known genotoxic and other adverse effects and has not been approved for the prevention or treatment of cancer cachexia

However, some authors recommend targeting 20-50 ug/mL

As NAD+ levels decline with age, obesity, and metabolic disease, sirtuin function diminishes, contributing to insulin resistance, mitochondrial dysfunction, and fat accumulation

doi: 10.1038/nrurol.2012.116
