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Sample sizes in (d): control male n = 5, control female n = 5, TRPM8 KO male n = 6, TRPM8 KO female n = 9, GluK2 cKO Pirt male n = 5, GluK2 cKO Pirt female n = 6, GluK2 cKO Pirt /TRPM8 KO male n = 5, GluK2 cKO Pirt /TRPM8 KO female n = 8 (mice)

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