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A second binding cavity, the H-site, is formed by three regions of the primary structure: 1) in the N-terminus contributions from residues 10,12 and the methylene groups of Arg13, Gly14, and Arg15

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Overall, simultaneous promotion of macrophage phagocytosis of MSU crystals and inhibition of MSU crystal-induced generation of inflammation may reduce the inflammatory response more rapidly.Therefore, inhibiting MSU crystal phagocytosis or reducing the expression of inflammatory factors post-phagocytosis may present an efficient therapeutic approach during MSU production
