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However, the interaction surface of p65 does not appear to include the DNA-binding domain, suggesting that inhibition may occur through allosteric modulation

Irina Sokolchik 5

The increased expression of EAAT1 has also been shown to increase the uptake of aspartate in breast, colon, and lung cancer allowing the growth of tumor cells in hypoxic conditions (45)

Reasons we do not know of yet and that are still being studied
