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However, it should not be ruled out that problems may already exist above this level

Medications like metformin (for diabetes), colchicine (for gout), and proton pump inhibitors (for acid reflux) can affect B12 levels

PMID: 37111227

For research that uses a vial over time rather than all at once, this is exactly what's needed and it's why bacteriostatic water, not plain sterile water, became the default for reconstituting peptides that come in multi-use formats
