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217 We also reported that lorlatinib sensitizes ferroptosis by inhibiting PI3K/AKT/mTOR-mediated SREBP1/SCD1 signaling axis via targeting insulin-like growth factor 1 receptor (IGF1R) and synergizes with RSL3 to inhibit melanoma

Avoid administration during or immediately after intense exercise
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For example, mitochondrial dynamin-like GTPase (OPA1), which regulates mitochondrial morphogenesis, fusion, and energy dynamics, can modulate cellular sensitivity to ferroptosis by regulating mtROS and integrating the cellular stress response [189]
