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Description
These structural changes are underpinned by activation of the PGC-1/fibronectin type III domain-containing protein 5 (FNDC5)/BDNF axis, with prolonged endurance training boosting BDNF synthesis across multiple brain regions [29]

A may be chelating copper ions away from the CNS via possible combined export across LRP1 (Wang et al., 2021), and or concurrently through direct sequestration of copper in the serum that would exit through urinary excretion, as abnormal A levels and ratios are a common feature AD patients urine (Yang et al., 2021)

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These clinical findings are particularly relevant for MCAS patients