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157 A partial explanation for the failure of the KD as a monotherapy in the ERGO trial could be based on the fact that there was no significant drop in blood glucose or HbA1c levels, and only part of the patients reached stable ketosis

& Owsianik, G
2025 Nov 1;161(11):1195

Despite the preclinical evidence supporting evaluation of IGF-targeted and endocrine therapy combinations, treatment with ganitumab plus the AI exemestane or ER antagonist fulvestrant did not improve PFS in women with previously treated hormone receptor-positive breast cancer, and OS was lower in the combination group versus endocrine treatment alone [197, 200]