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Int J Dev Neurosci

Today, drugs are known with proven efficacy for the prevention of major cardiovascular and cerebrovascular events: antiplatelets, ACE inhibitors, and lipid-lowering drugs (mainly statins, which additionally have a proven benefit for walking distance) [48]

In an eight-year follow-up study, no serious immediate or long-term complications attributable to spironolactone for treatment of acne were reported.[48] Still, mild side effects were present in 59 percent of the subjects, with menstrual irregularity being among the most common.[48] Hyperkalemia is often discussed as a potential concern

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